Author + information
- Anum S. Minhas, MD∗ ( and )
- Allison G. Hays, MD
- ↵∗Johns Hopkins Hospital, Division of Cardiology, 600 North Wolfe Street, Halsted 500, Baltimore, Maryland 21287
We would like to thank Dr. Reper and colleagues for their comments on our recent case report describing a patient with Takotsubo syndrome (TTS) triggered by coronavirus disease-2019 (COVID-19) (1), as well as for suggesting the use of the InterTAK Diagnostic Score for patients with TTS in this setting. For our patient, the calculated InterTAK score is 50 (25 points for female sex, 13 points for physical trigger, and 12 points for the absence of ST-segment depression). As stated in the original description of this score, “patients with 50 points have a probability of 18%…of suffering from TTS” (2). Although the InterTAK score may be helpful in other patients with TTS, in the case of our patient the score as calculated did not strongly support or refute a diagnosis of TTS. For our patient, the classic imaging pattern on the initial echocardiogram and the reversibility seen on a subsequent echocardiogram were more consistent with TTS, thus leading to our diagnosis. We acknowledge that this is the case of only 1 patient, and the utility of the InterTAK score should be assessed in a larger cohort of patients with possible TTS triggered by COVID-19 to understand the use of this score in this setting more clearly.
Please note: Dr. Minhas has received support from National Heart, Lung and Blood Institute (NHLBI) training grant T32HL007024. Dr. Hays has received support from the Magic that Matters Fund of Johns Hopkins Medicine and National Institutes of Health (NIH)/NHLBI grant 1R01HL147660.
The authors attest they are in compliance with human studies committees and animal welfare regulations of the authors’ institutions and Food and Drug Administration guidelines, including patient consent where appropriate. For more information, visit the JACC: Case Reports author instructions page.
- 2020 The Authors